Bioinformatics and expression analysis of the Xeroderma Pigmentosum complementation group C (XPC) of Trypanosoma evansi in Trypanosoma cruzi cells
نویسندگان
چکیده
Abstract Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved recognition of global genome DNA during NER (GG-NER) and it has been studied different organisms due to its importance other cellular processes. In this work, we proteins Trypanosoma cruzi evansi, parasites humans animals respectively. We performed three-dimensional models XPC from T. evansi observed few structural differences between these proteins. our tests, insertion gene (TevXPC) resulted slower cell growth under normal conditions. After cisplatin treatment, overexpressing own (TcXPC) was able recover division rates faster than expressing TevXPC gene. Based on suggested that (being an exogenous cruzi) interferes negatively processes where TcXPC (the endogenous protein) involved. This probably occurred interaction with some molecules or T.cruzi but incapacity others. reinforces the correctly functioning within cell.
منابع مشابه
XPC ( xeroderma pigmentosum , complementation group C )
Protein Description 939 amino acids. Expression Ubiquitous. Localisation Nuclear. Function Involved in the early recognition of DNA damage present in chromatine. Two proteins have been identified and implicated in (one of) the first steps of NER, i.e. the recognition of lesions in the DNA: the XPA gene product and the XPC gene product in complex with HR23B. This XPC-HR23B complex has been impli...
متن کاملXeroderma pigmentosum complementation group C protein (XPC) expression in basal cell carcinoma.
BACKGROUND The Xeroderma pigmentosum complementation group C protein (XPC) is a general sensor of damaged DNA. Individuals carrying a mutation in XPC genes exhibit marked photosensitivity and increased occurrence of skin cancers. Little is known about the distribution of XPC protein in basal cell carcinoma (BCC). AIM To determine whether the XPC protein is associated with basal cell carcinoma...
متن کاملERCC 4 ( xeroderma pigmentosum , complementation group F )
Xeroderma pigmentosum group F complementing factor; DNA-repair protein complementing XPF cells 905 amino acids; form a stable complex with the ERCC1 protein; The XPF protein and the ERCC1 protein form a complex that exhibits structure specific endonuclease activity that is responsible for the 5' incision during the NER reaction. XPF-ERCC1 also binds to XPA (through ERCC1) and to RPA (through XP...
متن کاملXPA ( xeroderma pigmentosum , complementation group A )
Initiates DNA repair by binding to damaged sites with various affinities, depending upon the chemical structure of the lesion. Two proteins have been identified and implicated in (one of) the first steps of Nucleotide Excision Repair (NER), i.e. the recognition of lesions in the DNA: the XPA gene product and the XPC gene product. Cells from XPA patients are extremely sensitive to UV and have ve...
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ژورنال
عنوان ژورنال: Brazilian Journal of Biology
سال: 2023
ISSN: ['1519-6984', '1678-4375']
DOI: https://doi.org/10.1590/1519-6984.243910